((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

Base Information

Chemical Name:((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol
CAS No.:1309384-31-3
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

Chemical Property:

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Technology Process of ((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

There total 5 articles about ((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: C₁₀H₂₀O₃

: 1309384-31-3
((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

Guidance literature:: With camphor-10-sulfonic acid; In 1,2-dichloro-ethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.02.053

Reference yield:

: 17247-58-4
(Bromomethyl)cyclobutane

: 1309384-31-3
((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide / acetone / 18 h / 60 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -40 °C

2.2: 16 h / -78 - 20 °C

2.3: -78 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

4.1: camphor-10-sulfonic acid / 1,2-dichloro-ethane / 4 h / 20 °C

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dichloro-ethane; acetone;
DOI:10.1016/j.bmc.2011.02.053

Reference yield:

: 1309384-24-4
(2S,3R)-diethyl 2-(cyclobutylmethyl)-3-hydroxy-2-methylsuccinate

: 1309384-31-3
((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

2: camphor-10-sulfonic acid / 1,2-dichloro-ethane / 4 h / 20 °C

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2011.02.053