(4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

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Chemical Name:(4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide
CAS No.:1309384-55-1
Molecular Formula:C₂₆H₄₀N₂O₅
Molecular Weight:460.614
Hs Code.:

Synonyms:(4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

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Chemical Property of (4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

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Technology Process of (4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

There total 10 articles about (4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 271591-61-8
3-amino-N-pentylpropanamide

: 1309384-47-1
C₁₈H₂₄O₅

: 1309384-55-1
(4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.02.053

Reference yield:

: 1309384-31-3
((4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methanol

: 1309384-55-1
(4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: sodium dihydrogenphosphate; sodium chlorite / dichloromethane; water; acetone / 0.25 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone; 1: Dess-Martin oxidation / 2: Pannick oxidation;
DOI:10.1016/j.bmc.2011.02.053

Reference yield:

: 17247-58-4
(Bromomethyl)cyclobutane

: 1309384-55-1
(4R,5R)-5-(cyclobutylmethyl)-2-(4-methoxyphenyl)-5-methyl-N-(3-oxo-3-(pentylamino)propyl)-1,3-dioxane-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium iodide / acetone / 18 h / 60 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -40 °C

2.2: 16 h / -78 - 20 °C

2.3: -78 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

4.1: camphor-10-sulfonic acid / 1,2-dichloro-ethane / 4 h / 20 °C

5.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

6.1: sodium dihydrogenphosphate; sodium chlorite / dichloromethane; water; acetone / 0.25 h / 20 °C

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; camphor-10-sulfonic acid; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; acetone; 5.1: Dess-Martin oxidation / 6.1: Pannick oxidation;
DOI:10.1016/j.bmc.2011.02.053