3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

Base Information

• Chemical Name: 3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
• CAS No.: 952709-96-5
• Molecular Formula: C₂₂H₂₀F₃NOS
• Molecular Weight: 403.468

Synonyms:3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

Chemical Property of 3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

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Technology Process of 3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

There total 1 articles about 3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

7-methoxy-3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin (952709-95-4) → 3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (952709-96-5)

Guidance literature:

7-methoxy-3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin; With tetrabutylammomium bromide; water; hydrogen bromide; acetic acid; at 100 ℃; for 16.5h;

With potassium carbonate; In water; pH=~ 10;

Reference yield: 79.0%

3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (952709-96-5) + ethyl bromoacetate (105-36-2) → {3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy}-acetic acid ethyl ester (952709-94-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 1h; Product distribution / selectivity; Heating / reflux;

Reference yield: 32.0%

α-bromo-γ-butyrolactone (5061-21-2) + 3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (952709-96-5) → 3-{3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy}-dihydro-furan-2-one (952710-75-7)

Guidance literature:

With potassium carbonate; In butanone; for 6h; Heating / reflux;

upstream raw materials:

7-methoxy-3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin

Downstream raw materials:

{3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy}-acetic acid ethyl ester

3-{3-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy}-dihydro-furan-2-one

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