3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

Base Information

Chemical Name:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)
CAS No.:1347656-20-5
Molecular Formula:C₂₅H₂₄F₅N₅O₂S
Molecular Weight:553.556
Hs Code.:

Synonyms:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

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Chemical Property of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

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Technology Process of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

There total 8 articles about 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347656-60-3
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

: 1347656-20-5
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

Guidance literature:: With N-methoxylamine hydrochloride; In methanol; at 60 ℃;

Reference yield:

: 1003320-13-5
1-(2-chloroacetyl)-N-(1,1-dimethylethyl)-4-piperidinecarboxamide

: 1347656-20-5
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 1.5 h / 37 - 55 °C

1.2: 10 °C / pH 5.5

2.1: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

3.1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

4.1: methanol / 20 °C

5.1: aluminum oxide / dichloromethane / 20 h / Reflux

6.1: N-methoxylamine hydrochloride / methanol / 60 °C

With aluminum oxide; hydrogen sulfide; N-methoxylamine hydrochloride; 2,2'-iminobis[ethanol]; potassium hydroxide; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinecarbonitrile

: 1347656-20-5
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-methyloxime)

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

2: methanol / 20 °C

3: aluminum oxide / dichloromethane / 20 h / Reflux

4: N-methoxylamine hydrochloride / methanol / 60 °C

With aluminum oxide; hydrogen sulfide; N-methoxylamine hydrochloride; 2,2'-iminobis[ethanol]; In methanol; dichloromethane; N,N-dimethyl-formamide;