3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

Base Information

Chemical Name:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one
CAS No.:1347656-60-3
Molecular Formula:C₂₄H₂₁F₅N₄O₂S
Molecular Weight:524.514
Hs Code.:

Synonyms:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

Suppliers and Price of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

There total 7 articles about 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 437-81-0
2,6-difluorobenzaldehyde

: 1152179-07-1
1-[4-(4-acetyl-1,3-thiazol-2-yl)piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

: 1347656-60-3
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

Guidance literature:: With aluminum oxide; In dichloromethane; for 20h; Reflux;

Reference yield:

: 1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinecarbonitrile

: 1347656-60-3
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

2: methanol / 20 °C

3: aluminum oxide / dichloromethane / 20 h / Reflux

With aluminum oxide; hydrogen sulfide; 2,2'-iminobis[ethanol]; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4395-98-6
4-cyanopiperidine

: 1347656-60-3
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dichloromethane; water / 1.25 h / -10 - 0 °C

2: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

3: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

4: methanol / 20 °C

5: aluminum oxide / dichloromethane / 20 h / Reflux

With aluminum oxide; hydrogen sulfide; potassium carbonate; 2,2'-iminobis[ethanol]; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;