Technology Process of (S)-2-Benzyloxycarbonylamino-2-methyl-3-trityloxy-propionic acid methyl ester
There total 8 articles about (S)-2-Benzyloxycarbonylamino-2-methyl-3-trityloxy-propionic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tert-butyl methyl ether; potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
DOI:10.1021/jo050407s
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dichloromethane / 0.5 h / 0 °C
2.1: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 30 h / -10 °C
3.1: sodium hydride
3.2: molecular sieves 4 Angstroem / 13 / 1 h / 20 °C
4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / methanol; acetone; tert-butyl alcohol / 3 h / 20 °C
5.1: sodium periodate / tetrahydrofuran; water / 2 h / 20 °C
6.1: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C
7.1: tert-butyl methyl ether; potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
With
sodium chlorite; sodium periodate; potassium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; tert-butyl methyl ether; carbon tetrabromide; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jo050407s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride
1.2: molecular sieves 4 Angstroem / 13 / 1 h / 20 °C
2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / methanol; acetone; tert-butyl alcohol / 3 h / 20 °C
3.1: sodium periodate / tetrahydrofuran; water / 2 h / 20 °C
4.1: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C
5.1: tert-butyl methyl ether; potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
With
sodium chlorite; sodium periodate; potassium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; tert-butyl methyl ether; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jo050407s
