cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

Base Information

Chemical Name:cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone
CAS No.:1357608-69-5
Molecular Formula:C₂₃H₁₇Cl₃F₄N₂O₂
Molecular Weight:535.753
Hs Code.:

Synonyms:cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

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Chemical Property of cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

Chemical Property:

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Technology Process of cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

There total 4 articles about cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357614-55-1
3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1357608-69-5
cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

Guidance literature:: With pyridine; at 20 ℃; for 1h;

Reference yield:

: 1357614-52-8
3-fluoro-3-(4-formyl-phenyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1357608-69-5
cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride / ethanol; water / 3 h / 20 - 50 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.2: 72 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

4.1: pyridine / 1 h / 20 °C

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1357614-53-9
3-fluoro-3-[4-(hydroxyimino-methyl)-phenyl]-azetidine-1-carboxylic acid tert-butyl ester

: 1357608-69-5
cyclopropyl(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

1.2: 72 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

3.1: pyridine / 1 h / 20 °C

With pyridine; N-chloro-succinimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;