3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
CAS No.:1357614-55-1
Molecular Formula:C₁₉H₁₃Cl₃F₄N₂O
Molecular Weight:467.678
Hs Code.:

Synonyms:3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Chemical Property of 3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Technology Process of 3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

There total 3 articles about 3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357614-54-0
tert-butyl 3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidine-1-carboxylate

: 1357614-55-1
3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: tert-butyl 3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; Inert atmosphere;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1357614-52-8
3-fluoro-3-(4-formyl-phenyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1357614-55-1
3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / ethanol; water / 3 h / 20 - 50 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.2: 72 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

With N-chloro-succinimide; hydroxylamine hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1357614-53-9
3-fluoro-3-[4-(hydroxyimino-methyl)-phenyl]-azetidine-1-carboxylic acid tert-butyl ester

: 1357614-55-1
3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

1.2: 72 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

With N-chloro-succinimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;