Technology Process of (2R,3S)-3-methyl-2-phenylindoline
There total 8 articles about (2R,3S)-3-methyl-2-phenylindoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; tert-butyl alcohol-d; diethoxymethylane; copper diacetate; triphenylphosphine;
In
tetrahydrofuran; tert-butyl methyl ether;
at 20 ℃;
for 24h;
Reagent/catalyst;
Solvent;
enantioselective reaction;
Catalytic behavior;
Inert atmosphere;
Sealed tube;
DOI:10.1021/jacs.5b02316
- Guidance literature:
-
With
lithium triethylborohydride;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
Schlenk technique;
DOI:10.1002/asia.201800121
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid / toluene / 18 h / 80 °C / Molecular sieve
2: copper diacetate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; triphenylphosphine; diethoxymethylane; tert-butyl alcohol-d / tetrahydrofuran; tert-butyl methyl ether / 24 h / 20 °C / Inert atmosphere; Sealed tube
With
(+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; tert-butyl alcohol-d; diethoxymethylane; copper diacetate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; tert-butyl methyl ether; toluene;
DOI:10.1021/jacs.5b02316
