(3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone

Base Information

• Chemical Name: (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone
• CAS No.: 174955-24-9
• Molecular Formula: C₂₂H₃₄O₃Si
• Molecular Weight: 374.596

Synonyms:(3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone

Chemical Property of (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone

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Technology Process of (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone

There total 4 articles about (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2,2-Dimethyl-4-{(R)-1-[4-((1S,5S)-5-trimethylsilanyl-3-trimethylsilanyloxy-cyclohex-2-enyl)-phenyl]-ethyl}-[1,3]dioxolane → (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone (174955-24-9)

Guidance literature:

With potassium fluoride; In methanol;

DOI:10.1016/S0040-4039(00)79970-9

Reference yield:

(S)-(+)-5-(trimethylsilyl)-2-cyclohexenone (116215-95-3) → (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone (174955-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, 2.) CuBr*SMe₂ / 2.) HMPA

2: KF / methanol

With potassium fluoride; copper(I) bromide dimethylsulfide complex; magnesium; In methanol;

DOI:10.1016/S0040-4039(00)79970-9

Reference yield:

(2R,3R)-3-(4-Bromo-phenyl)-butane-1,2-diol → (3R,5S,1'R,4''S)-3-(4-<1'-<2'',2''-dimethyl-1,3-dioxolan-4''-yl>ethyl>phenyl)-5-(trimethylsilyl)cyclohexanone (174955-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, 2.) CuBr*SMe₂ / 2.) HMPA

2: KF / methanol

With potassium fluoride; copper(I) bromide dimethylsulfide complex; magnesium; In methanol;

DOI:10.1016/S0040-4039(00)79970-9

upstream raw materials:

(S)-(+)-5-(trimethylsilyl)-2-cyclohexenone

Downstream raw materials:

(5S,1''R,2''S)-5-(4'-<2'',3''-dihydroxy-1''-methylpropyl>phenyl)-2-cyclohexenone

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