116215-95-3Relevant academic research and scientific papers
POLYCYCLIC CARBOGENIC MOLECULES AND USES THEREOF AS ANTI-CANCER AGENTS
-
Paragraph 0225; 0227; 0228, (2019/05/15)
Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical comp
A strategy for the convergent and stereoselective assembly of polycyclic molecules
Robinson, Emily E.,Thomson, Regan J.
supporting information, p. 1956 - 1965 (2018/02/17)
The stereoselective oxidative coupling of cyclic ketones via silyl bis-enol ethers followed by ring-closing metathesis is shown to be a general and powerful reaction sequence for the preparation of diverse polycyclic scaffolds from simple precursors. The
Organocatalytic asymmetric synthesis of 5-(trialkylsilyl)cyclohex-2-enones and the transformation into useful building blocks
Bolze, Patrick,Dickmeiss, Gustav,Jorgensen, Karl Anker
supporting information; experimental part, p. 3753 - 3756 (2009/07/01)
(Chemical Equation Presented) A simple organocatalytic approach to highly attractive chiral building blocks is presented. By the reaction of β-ketoesters with αβ-unsaturated aldehydes using a chiral IMS-protected prolinol as the catalyst, optically active 5-(trialkylsilyl) cyclohex-2-enones are formed in good yields and with 98-99% ee. The applications of 5-(trialkylsilyl)cyclohex-2-enones for the formation of 5-(hydroxy)cyclohex- 2-enones and the A-ring of 19-nor-1α,25-dihydroxyvitamin D3 are also presented.
Simple and practical routes to enantiomerically pure 5-(Trialkylsilyl)-2-cyclohexenones
Sarakinos, Georgios,Corey
, p. 811 - 814 (2008/02/12)
Formula presented Enantiomerically pure chiral 5-silylated 2-cyclohexenones are easily prepared in high yield using as a key step kinetic resolution with a commercially available lipase. Fully active enzyme can be recovered very efficiently for reuse. The
Enantioselective synthesis of the four isomers of the biologically active metabolite of the 2-arylpropanoic acid NSAID, ximoprofen, and assessment of their inhibitory activity on human platelet cyclo-oxygenase in vitro
Hamon,Hayball,Massy-Westropp,Newton,Tamblyn
, p. 263 - 272 (2007/10/03)
The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combinatin of Sharpless epoxidation followed by stereosele
Enantiocontrolled Synthesis of Optically Pure 5-Trimethylsilyl- and 5-Tributylstannyl-cyclohex-2-enones
Takano, Seiichi,Higashi, Yasuhiro,Kamikubo, Takashi,Moriya, Minoru,Ogasawara, Kunio
, p. 788 - 789 (2007/10/02)
Optically pure 5-trimethylsilyl- and 5-tributylstannyl-cyclohex-2-enones have been prepared efficiently in an enantiocontrolled manner starting from the common chiral precursor by employing a novel palladium-mediated elimination reaction as the key step.
SYNTHESIS OF (+)-α-CURCUMENE, (+)-CURCUMONE AND (-)-METHYL CITRONELLATE STARTING FROM OPTICALLY PURE 5-TRIMETHYLSILYL-2-CYCLOHEXENONE
Asaoka, Morio,Shima, Kunuhisa,Fujii, Naoaki,Takei, Hisashi
, p. 4757 - 4766 (2007/10/02)
1,4-addition of Grignard reagents in the presence of chlorotrimethylsilane to 5-trimethylsilyl-2-cyclohexanone (1) proceeded in a highly diastereoselective manner to give trans adducts in high yields. (+)-α-Curcumene, (+)-curcumone and (-)-methyl citronellate were synthesized starting from optically pure 1.
