1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Base Information

Chemical Name:1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole
CAS No.:108913-81-1
Molecular Formula:C₂₄H₂₈N₄O₄S
Molecular Weight:468.577
Hs Code.:

Synonyms:1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Suppliers and Price of 1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

There total 7 articles about 1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 108913-78-6
1-benzenesulfonyl-3-<2-(2,3-dioxopiperidino)ethyl>-2-hydroxymethylindole

: 57-14-7
N,N-Dimethylhydrazine

: 108913-81-1
1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Guidance literature:: With acetic acid; In methanol; for 1h;
DOI:10.1016/S0040-4020(01)87370-1

Reference yield:

: 69472-58-8
3-(2-aminoethyl)-2-hydroxymethylindole

: 108913-81-1
1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / KI, NaHCO₃ / methanol / Heating

2: 91 percent / N,N-diisopropylamine / CH₂Cl₂ / ice/acetone cooling, then RT

3: 1.) LDA / 1.) THF, -83 deg C, then RT; 2.) THF, -83 deg C, then RT

4: 18 percent / TsOH / acetone / 0.17 h / Ambient temperature

5: 79 percent / acetic acid / methanol / 1 h

With sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; diisopropylamine; potassium iodide; lithium diisopropyl amide; In methanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)87370-1

Reference yield:

: 85864-31-9
5-bromo-2,3-dimethoxypentanoic acid methyl ester

: 108913-81-1
1-benzenesulfonyl-3-<2-(3-dimethylhydrazono-2-oxopiperidino)ethyl>-2-hydroxymethylindole

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / KI, NaHCO₃ / methanol / Heating

2: 91 percent / N,N-diisopropylamine / CH₂Cl₂ / ice/acetone cooling, then RT

3: 1.) LDA / 1.) THF, -83 deg C, then RT; 2.) THF, -83 deg C, then RT

4: 18 percent / TsOH / acetone / 0.17 h / Ambient temperature

5: 79 percent / acetic acid / methanol / 1 h

With sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; diisopropylamine; potassium iodide; lithium diisopropyl amide; In methanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)87370-1