Technology Process of ethyl (2,3-dimethylphenyl)-2-oxoacetate
There total 1 articles about ethyl (2,3-dimethylphenyl)-2-oxoacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,3-dimethylbromobenzene;
With
iodine; magnesium;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
Inert atmosphere;
oxalic acid diethyl ester;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/acs.orglett.6b00748
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
ethyl (2,3-dimethylphenyl)-2-oxoacetate;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/acs.orglett.6b00748
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: lithium hydroxide / tetrahydrofuran; water / 80 °C
3.1: C48H50Cl4N2O2P2Ru3; sodium hydrogencarbonate; hydrogen / methanol / 24 h / 20 °C / 3750.38 Torr / Autoclave
4.1: potassium carbonate / acetone
With
C48H50Cl4N2O2P2Ru3; hydrogen; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; lithium hydroxide;
In
tetrahydrofuran; methanol; water; acetone;
DOI:10.1021/acs.orglett.6b00748
