(2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate

Base Information

• Chemical Name: (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate
• CAS No.: 884318-71-2
• Molecular Formula: C₂₆H₂₉NO₂Se
• Molecular Weight: 466.482
• Mol file: 884318-71-2.mol

Synonyms:(2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate

Chemical Property of (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate

There total 3 articles about (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-((R)-1-phenylethylimino)-4-phenyl-3-(phenylselanyl)butanoate (884318-64-3) → (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate (884318-71-2) + (2R,3R)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate (884318-72-3)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In ethanol; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2005.12.030

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate (884318-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄ / heptane; diethyl ether / 3.5 h / 0 - 20 °C

2: NaBH₃CN; AcOH / ethanol / 1 h / 0 °C

With titanium tetrachloride; sodium cyanoborohydride; acetic acid; In diethyl ether; ethanol; n-heptane;

DOI:10.1016/j.tet.2005.12.030

Reference yield:

2-Oxo-4-phenyl-3-phenylselanyl-butyric acid ethyl ester (200286-34-6) → (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate (884318-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄ / heptane; diethyl ether / 3.5 h / 0 - 20 °C

2: NaBH₃CN; AcOH / ethanol / 1 h / 0 °C

With titanium tetrachloride; sodium cyanoborohydride; acetic acid; In diethyl ether; ethanol; n-heptane;

DOI:10.1016/j.tet.2005.12.030

upstream raw materials:

ethyl 2-((R)-1-phenylethylimino)-4-phenyl-3-(phenylselanyl)butanoate

(R)-1-phenyl-ethyl-amine

2-Oxo-4-phenyl-3-phenylselanyl-butyric acid ethyl ester

Downstream raw materials:

ethyl (2R,3R)-3-benzyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate