Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

Base Information

• Chemical Name: Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester
• CAS No.: 152953-43-0
• Molecular Formula: C₄₃H₅₄O₈
• Molecular Weight: 698.897
• Mol file: 152953-43-0.mol

Synonyms:Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

Chemical Property of Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

There total 7 articles about Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

acryloyl chloride (814-68-6,25189-84-8) + Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester (161882-45-7) → Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester (152953-43-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1021/jo00107a015

Reference yield:

methyl 3α,12α-diacetyloxy-7α-hydroxy-5β-cholan-24-oate (58822-33-6) → Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester (152953-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / CaH₂, n-Bu₄NI / toluene / Heating

2: 96 percent / K₂CO₃ / methanol / Ambient temperature

3: 83 percent / Et₃N / CH₂Cl₂ / 0 °C

With calcium hydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo00107a015

Reference yield:

methyl 3α,12α-dihydroxy-7-oxo-5β-cholate (15073-97-9,15180-34-4,81644-39-5,81644-40-8,10538-65-5) → Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester (152953-43-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / DMAP, Et₃N / 24 h / Ambient temperature

2: 83 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 83 percent / CaH₂, n-Bu₄NI / toluene / Heating

4: 96 percent / K₂CO₃ / methanol / Ambient temperature

5: 83 percent / Et₃N / CH₂Cl₂ / 0 °C

With dmap; sodium tetrahydroborate; calcium hydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo00107a015

upstream raw materials:

acryloyl chloride

Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester

methyl 3α,12α-diacetyloxy-7α-hydroxy-5β-cholan-24-oate

methyl 3α,12α-dihydroxy-7-oxo-5β-cholate