(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

Base Information

Chemical Name:(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester
CAS No.:866395-27-9
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

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Chemical Property of (2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

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Technology Process of (2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

There total 10 articles about (2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 866395-24-6
(S)-1-mesyloxy-N-(benzyloxycarbonyl)-3-amino-4-phenylbutane

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 866395-27-9
(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 - 50 ℃;
DOI:10.1016/j.tet.2005.07.049

Reference yield:

: 348184-48-5
(S)-N-(benzyloxycarbonyl)-3-amino-4-phenylbutan-1-ol

: 866395-27-9
(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Et₃N / CH₂Cl₂ / cooling

2: 64 percent / Et₃N / acetonitrile / 20 - 50 °C

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2005.07.049

Reference yield:

: 866395-50-8
methyl (R)-3-phthalimido-4-phenylbutyrate

: 866395-27-9
(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: LiBH₄ / tetrahydrofuran; H₂O / 1 h

2: AcOH / 80 °C

3: aq. NaOH / CH₂Cl₂ / 20 °C

4: 99 percent / Et₃N / CH₂Cl₂ / cooling

5: 64 percent / Et₃N / acetonitrile / 20 - 50 °C

With sodium hydroxide; lithium borohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2005.07.049