(2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Base Information

Chemical Name:(2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester
CAS No.:866395-33-7
Molecular Formula:C₃₉H₅₀N₄O₅
Molecular Weight:654.85
Hs Code.:

Synonyms:(2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Suppliers and Price of (2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

There total 12 articles about (2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 866395-42-8
(S)-1-((R)-3-Benzyloxycarbonylamino-4-phenyl-butyl)-pyrrolidine-2-carboxylic acid

: (S)-1-((R)-3-Amino-4-phenyl-butyl)-pyrrolidine-2-carboxylic acid methyl ester; hydrochloride

: 866395-33-7
(2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Guidance literature:: With triethylamine; isobutyl chloroformate; In dichloromethane; at -20 - 20 ℃;
DOI:10.1016/j.tet.2005.07.049

Reference yield:

: 866395-27-9
(2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester

: 866395-33-7
(2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. NaOH / methanol / Heating

2: 75 percent / Et₃N; i-BuOCOCl / CH₂Cl₂ / -20 - 20 °C

With sodium hydroxide; triethylamine; isobutyl chloroformate; In methanol; dichloromethane;
DOI:10.1016/j.tet.2005.07.049

Reference yield:

: 866395-47-3
(R)-1-diazo-3-phthalimido-4-phenylbutan-2-one

: 866395-33-7
(2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / PhCO₂Ag; Et₃N / 2 h / Heating

2: LiBH₄ / tetrahydrofuran; H₂O / 1 h

3: AcOH / 80 °C

4: aq. NaOH / CH₂Cl₂ / 20 °C

5: 99 percent / Et₃N / CH₂Cl₂ / cooling

6: 64 percent / Et₃N / acetonitrile / 20 - 50 °C

7: 95 percent / aq. NaOH / methanol / Heating

8: 75 percent / Et₃N; i-BuOCOCl / CH₂Cl₂ / -20 - 20 °C

With sodium hydroxide; lithium borohydride; silver benzoate; acetic acid; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1: Wolff rearrangement;
DOI:10.1016/j.tet.2005.07.049