Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

Base Information

Chemical Name:Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester
CAS No.:129419-12-1
Molecular Formula:C₂₂H₁₉N₃O₃
Molecular Weight:373.411
Hs Code.:

Synonyms:Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

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Chemical Property of Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

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Technology Process of Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

There total 3 articles about Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 10400-19-8
3-pyridinecarbonyl chloride

: 79707-34-9
3-(hydroxymethyl)-2-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine

: 129419-12-1
Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 3h;
DOI:10.1021/jm00145a006

Reference yield:

: 24016-03-3
2-amino-3-benzyloxypyridine

: 129419-12-1
Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 28 percent / ethanol / 20 h / Heating

2: 65 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 - 5 °C

3: 94 percent / triethylamine / CH₂Cl₂ / 3 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00145a006

Reference yield:

: 96428-50-1
2-carboethoxy-3-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine

: 129419-12-1
Nicotinic acid 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 - 5 °C

2: 94 percent / triethylamine / CH₂Cl₂ / 3 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00145a006