(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

Base Information

Chemical Name:(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene
CAS No.:270258-32-7
Molecular Formula:C₃₀H₃₈O₃SSi
Molecular Weight:506.781
Hs Code.:

Synonyms:(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

Suppliers and Price of (R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

Chemical Property:

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Technology Process of (R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

There total 9 articles about (R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 270258-30-5
(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-2-hexen-1-ol

: 270258-32-7
(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

Guidance literature:: Multi-step reaction with 2 steps

1: CCl₄; PPh₃ / 6 h / Heating

2: dimethylformamide / 15 h / 20 °C

With tetrachloromethane; triphenylphosphine; In N,N-dimethyl-formamide; 1: Chlorination / 2: Substitution;
DOI:10.1002/(sici)1099-0690(200003)2000:6<955::aid-ejoc955>3.0.co;2-y

Reference yield:

: 126616-47-5
(R)-(-)-4-tert-butyldiphenylsilyloxy-1-methylbutanal

: 270258-32-7
(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

Guidance literature:: Multi-step reaction with 6 steps

1.1: PPh₃ / CH₂Cl₂

2.1: 98 percent / BuLi / diethyl ether

3.1: Cp₂ZrCl₂; water / CH₂Cl₂

4.1: BuLi / hexane

4.2: tetrahydrofuran

5.1: CCl₄; PPh₃

6.1: dimethylformamide

With tetrachloromethane; n-butyllithium; zirconocene dichloride; water; triphenylphosphine; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Addition / 2.1: Dehydrochlorination / 3.1: Addition / 4.1: Metallation / 4.2: Condensation / 5.1: Substitution / 6.1: Substitution;
DOI:10.1039/a907910f

Reference yield:

: 156757-31-2
(3R)-4-(tert-butyldimethylsilanyloxy)-3-methylbutyraldehyde

: 270258-32-7
(R,E)-6-(tert-butyldiphenylsilyloxy)-3,4-dimethyl-1-phenylsulfonyl-2-hexene

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaBH₄ / ethanol

2.1: 89 percent / imidazole / dimethylformamide

3.1: 84 percent / AcOH; H₂O / tetrahydrofuran

5.1: PPh₃ / CH₂Cl₂

6.1: 98 percent / BuLi / diethyl ether

7.1: Cp₂ZrCl₂; water / CH₂Cl₂

8.1: BuLi / hexane

8.2: tetrahydrofuran

9.1: CCl₄; PPh₃

10.1: dimethylformamide

With 1H-imidazole; tetrachloromethane; sodium tetrahydroborate; n-butyllithium; zirconocene dichloride; water; acetic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Substitution / 3.1: Hydrolysis / 4.1: Oxidation / 5.1: Addition / 6.1: Dehydrochlorination / 7.1: Addition / 8.1: Metallation / 8.2: Condensation / 9.1: Substitution / 10.1: Substitution;
DOI:10.1039/a907910f