1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Base Information

Chemical Name:1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one
CAS No.:1346672-60-3
Molecular Formula:C₁₆H₂₁BN₄O₃
Molecular Weight:328.179
Hs Code.:

Synonyms:1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Suppliers and Price of 1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Alichem
1-Methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1h)-one
1g
$ 844.48

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Chemical Property of 1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Chemical Property:

Boiling Point:411.4±55.0 °C(Predicted)
Density:1.22±0.1 g/cm3(Predicted)

Purity/Quality:: 1-Methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1h)-one ^*data from reagent suppliers

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Technology Process of 1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

There total 3 articles about 1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1346672-61-4
5-bromo-1-methyl-3-(pyrimidin-4-ylamino)pyridin-2(1H)-one

: 73183-34-3
bis(pinacol)diborane

: 1346672-60-3
1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; In 1,4-dioxane; at 60 ℃; for 8h; Inert atmosphere;

Reference yield: 71.0%

: 1346672-61-4
5-bromo-1-methyl-3-(pyrimidin-4-ylamino)pyridin-2(1H)-one

: 1346672-60-3
1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Guidance literature:: 5-bromo-1-methyl-3-(pyrimidin-4-ylamino)pyridin-2(1H)-one; With potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; for 0.5h; Inert atmosphere; Reflux;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; for 1h; Reflux;

Reference yield:

: 14529-54-5
3,5-dibromo-1-methyl-1H-pyridin-2-one

: 1346672-60-3
1-methyl-3-(pyrimidin-4-ylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 130 °C / sealed tube

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 95 °C / Inert atmosphere

With potassium acetate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;