(S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate

Base Information

• Chemical Name: (S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate
• CAS No.: 1321530-55-5
• Molecular Formula: C₂₂H₃₀O₃Si
• Molecular Weight: 370.564
• Mol file: 1321530-55-5.mol

Synonyms:(S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate

Chemical Property of (S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate

There total 2 articles about (S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-methyl 2-(((tert-butyldimethylsilyl)oxy)methyl)but-2-enoate (1321530-50-0) → (S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate (1321530-55-5) + (R)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate (1321530-52-2)

Guidance literature:

With C₂₆H₂₂NOP*C₃₂H₁₂BF₂₄^(1-)*C₈H₁₂*Ir⁽¹⁺⁾; hydrogen; In dichloromethane; at 20 ℃; for 16h; under 37503.8 Torr; Overall yield = 100 %; Overall yield = 184 mg; Autoclave;

DOI:10.1055/s-0033-1340868

Reference yield:

methyl (2E)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-butenoate (146983-20-2) → (S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate (1321530-55-5) + (R)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate (1321530-52-2)

Guidance literature:

With C₃₁H₄₂IrNOP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen; In dichloromethane; at 20 ℃; for 2h; under 56255.6 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ol201692h

Reference yield: 82.0%

(S)-methyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)butanoate (1321530-55-5) → (2S)-2-ethyl-3-[(tert-butyldiphenylsilyl)oxy]propanal (339533-79-8)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1055/s-0033-1340868

upstream raw materials:

methyl (2E)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-butenoate

(E)-methyl 2-(((tert-butyldimethylsilyl)oxy)methyl)but-2-enoate

Downstream raw materials:

C₂₉H₃₁NO₆

(2S)-2-ethyl-3-[(tert-butyldiphenylsilyl)oxy]propanal

ethyl (R,E)-4-[(tert-butyldiphenylsiloxy)methyl]-2-methylhex-2-enoate

(R,E)-4-[(tert-butyldiphenylsiloxy)methyl]-2-methylhex-2-en-1-ol