4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide

Base Information

• Chemical Name: 4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide
• CAS No.: 1202920-37-3
• Molecular Formula: C₂₆H₂₄ClN₃O₄
• Molecular Weight: 477.947
• Mol file: 1202920-37-3.mol

Synonyms:4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide

Chemical Property of 4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide

There total 1 articles about 4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide (747413-05-4) → 4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide (1202920-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

2: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

With water; nitric acid; acetic anhydride; ammonium chloride; zinc; In tetrahydrofuran;

DOI:10.1021/jm201155e

Reference yield:

4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide (1202920-37-3) + acetyl chloride (75-36-5) → 4-acetylamino-5-(2,4-bis-benzyloxy-5-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide (1202920-38-4)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

4-amino-5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid ethylamide (1202920-37-3) → 5-(2,4-dihydroxy-5-chlorophenyl)-4-amino-isoxazole-3-carboxylic acid ethylamide (1202921-49-0)

Guidance literature:

With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1021/jm201155e

upstream raw materials:

5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide

Downstream raw materials:

4-acetylamino-5-(2,4-bis-benzyloxy-5-chloro-phenyl)-isoxazole-3-carboxylic acid ethylamide

5-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-[(3-methyl-thiophene-2-carbonyl)-amino]-isoxazole-3-carboxylic acid ethylamide

5-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-(3-morpholin-4-yl-propionylamino)isoxazole-3-carboxylic acid ethylamide

5-(5-chloro-2,4-dihydroxy-phenyl)-4-(3-morpholin-4-yl-propionylamino)isoxazole-3-carboxylic acid ethylamide