Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)-

Base Information

Chemical Name:Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)-
CAS No.:122744-79-0
Molecular Formula:C₁₆H₂₅N₃O₃
Molecular Weight:307.393
Hs Code.:
DSSTox Substance ID:DTXSID401146150

Synonyms:DTXSID401146150;Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)-;122744-79-0

Suppliers and Price of Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)-

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:307.18959167
Heavy Atom Count:22
Complexity:367

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=C(C=CC(=C2OC)OC)N
Isomeric SMILES:CCN1CCC[C@H]1CNC(=O)C2=C(C=CC(=C2OC)OC)N

Technology Process of Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)-

There total 4 articles about Benzamide, 6-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-Azido-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dimethoxy-benzamide

: 122744-79-0
(S)-6-amino-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide

Guidance literature:: With tin(ll) chloride; In methanol; for 1.5h; Yield given; Ambient temperature;
DOI:10.1021/jo00280a020

Reference yield:

: 107188-81-8
(-)-(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2,3-dimethoxybenzamide

: 122744-79-0
(S)-6-amino-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium, 2.) p-toluenesulfonyl azide / 1.) THF, hexane, RT, 20 min, 2.) RT, 20 min

2: tin(II) chloride hydrate / methanol / 1.5 h / Ambient temperature

With n-butyllithium; 4-toluenesulfonyl azide; tin(ll) chloride; In methanol;
DOI:10.1021/jo00280a020

Reference yield:

: 102421-43-2
N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline

: 122744-79-0
(S)-6-amino-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) hexane, THF, -10 to -20 deg C, 2 h, 2.) THF

2: 1.) thionyl chloride, DMF / 1.) toluene, 60 deg C, 1.5 h, 2.) CH₂Cl₂

With n-butyllithium; thionyl chloride; N,N-dimethyl-formamide;
DOI:10.1021/jo00280a020