6-((Tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid

Base Information

• Chemical Name: 6-((Tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid
• CAS No.: 106107-48-6
• Molecular Formula: C14H19NO6
• Molecular Weight: 297.308
• DSSTox Substance ID: DTXSID70560000
• Wikidata: Q82442938
• Mol file: 106107-48-6.mol

Synonyms:6-((tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid;106107-48-6;6-[(tert-Butoxycarbonyl)amino]-2,3-dimethoxybenzoic acid;SCHEMBL5305447;DTXSID70560000;UZURLYMZJFHVLN-UHFFFAOYSA-N;6-tert-butoxycarbonylamino-2,3-dimethoxy-benzoic acid

Chemical Property of 6-((Tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 297.12123733
• Heavy Atom Count: 21
• Complexity: 378

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1=C(C(=C(C=C1)OC)OC)C(=O)O

Technology Process of 6-((Tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid

There total 5 articles about 6-((Tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.5%

carbon dioxide (124-38-9,18923-20-1) + N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline (102421-43-2) → 6-((tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid (106107-48-6)

Guidance literature:

N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline; With n-butyllithium; In tetrahydrofuran; at -78 - -10 ℃; for 2h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; pH=1 - 2; Inert atmosphere;

Reference yield:

n-butyllithium (109-72-8,29786-93-4) + N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline (102421-43-2) → 6-((tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid (106107-48-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 6-((tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid (106107-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -10 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: pH 1 - 2 / Inert atmosphere

With n-butyllithium; In tetrahydrofuran;

upstream raw materials:

carbon dioxide

N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline

n-butyllithium

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-6-amino-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide

6-bromo-2-carboxy-3,4-dimethoxy-N-(tert-butoxycarbonyl)aniline

(S)-2-amino-3-bromo-N-<(1-ethyl-2-pyrrolidinyl)methyl>-5,6-dimethoxybenzamide

6-amino-2,3-dimethoxybenzoic acid