4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

Base Information

Chemical Name:4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid
CAS No.:1087353-56-7
Molecular Formula:C₁₅H₁₂FNO₄
Molecular Weight:289.263
Hs Code.:

Synonyms:4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

Chemical Property:

Boiling Point:412.9±45.0 °C(Predicted)
Density:1.402±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of 4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

There total 6 articles about 4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 446-31-1
2-fluoro-4-aminobenzoic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 1087353-56-7
4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

Guidance literature:: 2-fluoro-4-aminobenzoic acid; With sodium hydrogencarbonate; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

benzyl chloroformate; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1016/j.bmcl.2017.10.018

Reference yield: 92.0%

: 324788-98-9
tert-butyl 4-benzyloxycarbonylamino-2-fluoro-benzoate

: 1087353-56-7
4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 1087353-56-7
4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: chromium(VI) oxide; sulfuric acid; acetic acid / water / 3 h / 100 °C

2: triethylamine / dmap / dichloromethane / 2 h / 10 - 20 °C

3: iron; ammonium chloride / ethanol; water / 1 h / 95 °C

4: sodium hydrogencarbonate / tetrahydrofuran / 19 h / 0 - 50 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

With chromium(VI) oxide; sulfuric acid; iron; sodium hydrogencarbonate; ammonium chloride; acetic acid; triethylamine; trifluoroacetic acid; dmap; In tetrahydrofuran; ethanol; dichloromethane; water;