[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

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Chemical Name:[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile
CAS No.:128291-15-6
Molecular Formula:C₃₀H₃₉NO₂Si
Molecular Weight:473.731
Hs Code.:

Synonyms:[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

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Chemical Property of [(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

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Technology Process of [(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

There total 11 articles about [(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19184-67-9
methyl 3,3-dimethylglutarate

: 128291-15-6
[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) LDA / 1.) THF, -78 deg C, 2.) r.t., 2h

2: 96 percent / LAH / tetrahydrofuran / 0 °C

3: 96 percent / imidazole / dimethylformamide / -30 °C

4: 1) PCC 2) NaH / 1) CH₂Cl₂, r.t. 2) THF

5: 1) HF, 2) PCC / 1) acetonitrile, r.t. 2) CH₂Cl₂, r.t.

6: 1) e-(Hg, SCE), CH₂(CO₂CH₃)2, n-Bu₄NBr, 2) LAH / 1) CH₃CN 2) THF, 0 deg C

7: 96 percent / imidazole / CH₂Cl₂ / 0 °C

8: PCC / CH₂Cl₂ / Ambient temperature

9: 1) NaH / 1) THF, r.t.

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; tetrabutylammomium bromide; sodium hydride; pyridinium chlorochromate; malonic acid dimethyl ester; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(90)87014-Q

Reference yield:

: 128291-05-4
2-Allyl-3,3-dimethyl-pentane-1,5-diol

: 128291-15-6
[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / imidazole / dimethylformamide / -30 °C

2: 1) PCC 2) NaH / 1) CH₂Cl₂, r.t. 2) THF

3: 1) HF, 2) PCC / 1) acetonitrile, r.t. 2) CH₂Cl₂, r.t.

4: 1) e-(Hg, SCE), CH₂(CO₂CH₃)2, n-Bu₄NBr, 2) LAH / 1) CH₃CN 2) THF, 0 deg C

5: 96 percent / imidazole / CH₂Cl₂ / 0 °C

6: PCC / CH₂Cl₂ / Ambient temperature

7: 1) NaH / 1) THF, r.t.

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; tetrabutylammomium bromide; sodium hydride; pyridinium chlorochromate; malonic acid dimethyl ester; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(90)87014-Q

Reference yield:

: 128291-11-2,128387-68-8
(2R,3R)-3-Allyl-2-(2-hydroxy-ethyl)-4,4-dimethyl-cyclopentanol

: 128291-15-6
[(2S,3S)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,4-dimethyl-3-(3-oxo-propyl)-cyclopent-(E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / imidazole / CH₂Cl₂ / 0 °C

2: PCC / CH₂Cl₂ / Ambient temperature

3: 1) NaH / 1) THF, r.t.

With 1H-imidazole; sodium hydride; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/0040-4039(90)87014-Q