(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Base Information

• Chemical Name: (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide
• CAS No.: 1027345-14-7
• Molecular Formula: C₁₉H₂₄F₃N₃O₄S₃
• Molecular Weight: 511.61

Synonyms:(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Chemical Property of (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

There total 3 articles about (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(R)-N1,N1-dimethyl-4-(phenylthio)butane-1,3-diamine (870812-32-1) + 4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide (1027345-08-9) → (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide (1027345-14-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 100 ℃; for 6h;

Reference yield: 67.0%

(R)-N,N-dimethyl-4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanamide (1027345-13-6) → (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide (1027345-14-7)

Guidance literature:

(R)-N,N-dimethyl-4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanamide; With borane-THF; In tetrahydrofuran; at 20 - 55 ℃; for 26h;

With hydrogenchloride; methanol; at 0 - 65 ℃; for 10h;

Reference yield:

→ (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide (1027345-14-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 25 ℃;

upstream raw materials:

(R)-N,N-dimethyl-4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanamide

(R)-N¹,N¹-dimethyl-4-(phenylthio)butane-1,3-diamine

4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

Downstream raw materials:

N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

N-(7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazolin-4-yl)-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

4-[4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-2-trifluoromethyl-5,8-dihydro-6Hpyrido[3,4-d]pyrimidine-7-carboxylic acid

(R)-tert-butyl 3-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenylsulfonamido)-8,9-dihydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepine-7(6H)-carboxylate

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