(S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

Base Information

Chemical Name:(S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate
CAS No.:1456507-13-3
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:(S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

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Chemical Property of (S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

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Technology Process of (S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

There total 4 articles about (S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

: 7473-98-5
2-hydroxy-2-methylpropiophenone

: 1437789-93-9
3-((1R,4R)-4-aminocyclohexyl)-1H-imidazo-[4,5-b]pyridin-2(3H)-one

: 1437789-95-1
(+/-)-3-((1R,4R)-4-((2-hydroxy-2-methyl-1-phenylpropyl)amino)cyclohexyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one

: 1456507-13-3
(S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield: 5.5%

: 179321-24-5
1-(4-oxocyclohexyl)-1H-benzo[d]imidazol-2(3H)-one

: 15028-39-4,13226-98-7
L-2-phenylglycine methyl ester hydrochloride

: 1456507-12-2
(S)-methyl 2-(((1r,4S)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

: 1456507-13-3
(S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

Reference yield:

: 179321-23-4
1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-benzo[d]imidazol-2(3H)-one

: 1456507-13-3
(S)-methyl 2-(((1s,4R)-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexyl)amino)-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / water; acetone / Reflux

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 4 h / 20 °C

With pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; acetic acid; In water; 1,2-dichloro-ethane; acetone;