(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

Base Information

Chemical Name:(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine
CAS No.:330784-23-1
Molecular Formula:C₁₉H₂₃ClN₄O₃
Molecular Weight:390.87
Hs Code.:

Synonyms:(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

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Chemical Property of (S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

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Technology Process of (S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

There total 6 articles about (S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 330785-87-0
4-(3-Chloro-4-methoxy-benzylamino)-2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-pyrimidine-5-carbaldehyde

: 917-54-4
methyllithium

: 330784-23-1
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

Guidance literature:: 4-(3-Chloro-4-methoxy-benzylamino)-2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-pyrimidine-5-carbaldehyde; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃;

With manganese(IV) oxide; In tetrahydrofuran; diethyl ether; chloroform; at 20 ℃;
DOI:10.1016/j.bmcl.2015.02.041

Reference yield:

: 330785-81-4
ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate

: 330784-23-1
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C

3.2: 0 °C

4.1: tetrahydrofuran; diethyl ether / -78 °C

4.2: 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/j.bmcl.2015.02.041

Reference yield:

: 330786-34-0
4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 330784-23-1
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-acetylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C

2.2: 0 °C

3.1: tetrahydrofuran; diethyl ether / -78 °C

3.2: 20 °C

With manganese(IV) oxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/j.bmcl.2015.02.041