330785-81-4 Usage
Description
(5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester) is an organic compound that serves as an intermediate for Avanafil (A794670) derivatives. It is characterized by its unique chemical structure, which includes a pyrimidinecarboxylic acid core, a chloro-methoxyphenylmethylamino group, and a methylthiomethyl ester functional group. (5-PyriMidinecarboxylicacid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester) plays a crucial role in the synthesis of Avanafil, a phosphodiesterase (PDE5) inhibitor used for treating erectile dysfunction.
Uses
Used in Pharmaceutical Industry:
(5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester) is used as a key intermediate in the synthesis of Avanafil, a PDE5 inhibitor, for the treatment of erectile dysfunction. Its role in the production of Avanafil is essential, as it contributes to the development of a medication that helps improve the quality of life for patients suffering from this condition.
Used in Research and Development:
(5-PyriMidinecarboxylicacid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester) is also utilized in research and development for the discovery and development of new PDE5 inhibitors and other related pharmaceuticals. Its unique chemical structure makes it a valuable tool for understanding the interactions between PDE5 enzymes and potential therapeutic agents, ultimately leading to the creation of more effective treatments for various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 330785-81-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,0,7,8 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 330785-81:
(8*3)+(7*3)+(6*0)+(5*7)+(4*8)+(3*5)+(2*8)+(1*1)=144
144 % 10 = 4
So 330785-81-4 is a valid CAS Registry Number.
330785-81-4Relevant articles and documents
A kind of avanafil impurity D and synthesis method and application thereof
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, (2022/01/12)
The present invention provides a new aphranarfil impurity and synthesis method thereof, by synthesizing and characterizing the impurity, the structure of the impurity is determined, the drug impurity profile of avanafil is perfected, the resulting product is of high purity, can be used as a control for drug quality control research.
A process for the preparation of atorvastatin that non-intermediate and its preparation method
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Paragraph 0035; 0036-0038; 0053-0055; 0069-0071; 0085-0087, (2017/08/25)
The invention provides a novel intermediate IV which is used for preparation of avanafil. The intermediate has a general formula IV as described in the specification; and in the general formula IV, R represents a C1-20 alkylsulfinyl group or a C1-20 alkylsulfonyl group. The intermediate has high purity, is suitable for industrial production and can be subjected to a one-step chemical reaction to prepare avanafil. The invention also provides a preparation method for the intermediate and a method for preparing avanafil from the intermediate.
Prodrugs Of Bicyclic Substituted Pyrimidine Type PDE-5 Inhibitors
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Paragraph 0204; 0205, (2016/03/13)
Provided are prodrugs of a bicyclic substituted pyrimidine type PDE-5 inhibitors, pharmaceutically acceptable salts or stereoisomers thereof. Also provided are methods for preparing these prodrug compounds, pharmaceutical preparations, and pharmaceutical compositions, as well as a use of these compounds, pharmaceutical preparations and pharmaceutical compositions in the manufacture of medicaments for treatment and/or prophylaxis of sexual dysfunction and lower urinary tract symptoms.