2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

Base Information

Chemical Name:2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile
CAS No.:1378040-83-5
Molecular Formula:C₁₃H₅BrClFN₆
Molecular Weight:379.578
Hs Code.:

Synonyms:2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

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Chemical Property of 2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

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Technology Process of 2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

There total 3 articles about 2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378039-78-1
4-azido-5-fluoro-pyridine-3-carbaldehyde

: 914636-86-5
2-amino-5-bromo-3-chlorobenzonitrile

: 1378040-83-5
2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

Guidance literature:: With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 2546-56-7
4-chloro-3-fluoro-pyridine

: 1378040-83-5
2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 18.75 h / -78 - -30 °C

1.2: 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: triethylamine; titanium tetrachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; titanium tetrachloride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1060802-34-7
4-chloro-5-fluoropyridine-3-carboxaldehyde

: 1378040-83-5
2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chloro benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2: triethylamine; titanium tetrachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium azide; titanium tetrachloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;