2546-56-7

Basic information

• Product Name: 4-Chloro-3-fluoropyridine
• Synonyms: 4-CHLORO-3-FLUOROPYRIDINE;3-FLUORO-4-CHLORO PYRIDINE;2-Methyl-4-ChloropyridineHydrochloride;4-CHLORO-3-FLUOROPYRIDINE 4-CHLORO-3-FLUOROPYRIDINE;Chlorofluoropyridine 43---;4-Chloro-3-fluoropyridine >=95.0%
• CAS NO: 2546-56-7
• Molecular Formula: C₅H₃ClFN
• Molecular Weight: 131.54
• EINECS: -0
• Product Categories: Fluorin-contained pyridine series;Pyridine;Heterocyclic Series;Pyridines;Heterocycles;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles
• Mol File: 2546-56-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: -24°C(lit.)
• Boiling Point: 139°C(lit.)
• Flash Point: 82.4 °F
• Appearance: Light yellow liquid
• Density: 1.333 g/mL at 25 °C(lit.)
• Vapor Pressure: 8.19mmHg at 25°C
• Refractive Index: 1.5010 to 1.5050
• Storage Temp.: 2-8°C
• PKA: 1.93±0.10(Predicted)
• BRN: 1422747
• CAS DataBase Reference: 4-Chloro-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-fluoropyridine(2546-56-7)
• EPA Substance Registry System: 4-Chloro-3-fluoropyridine(2546-56-7)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 10-36/37/38-20/21/22
• Safety Statements: 16-26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 2546-56-7(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

InChI:InChI=1/C5H3ClFN/c6-4-1-2-8-3-5(4)7/h1-3H

Upstream product

• 372-47-4 3-Fluoropyridine 
• 851178-98-8 3-chloro-4,5-difluoropyridine 
• 851179-02-7 3,4-dichloro-5-fluoropyridine 
• 248255-70-1 5-chloro-3-fluoro-2-hydrazinylpyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 514797-99-0 3-chloro-5-fluoro-pyridine 
• 119229-74-2 4-chloro-3-fluoropyridine hydrochloride 
• 2247-88-3 3-fluoro-pyridin-4-ylamine 

Downstream Products

• 860296-21-5 4-chloro-3-fluoropyridine-2-carboxylic acid 
• 928322-46-7 3-fluoro-4-(4-nitrophenyl)pyridine 
• 1060802-34-7 4-chloro-5-fluoropyridine-3-carboxaldehyde 
• 1086107-76-7 6-(4-chloropyridin-3-yloxy)-N-(cyclohexylmethyl)benzo[d]thiazol-2-amine 
• 1155847-42-9 2-bromo-4-chloro-3-fluoropyridine 
• 1007572-17-9 C₂₀H₁₂BrClF₂N₂O₂ 
• 1060805-03-9 3-fluoro-4-methoxypyridine 
• 1454913-74-6 (4-(4-chloro-2-fluorophenyl)-5-fluoropyridin-3-yl)methanol 
• 1260878-78-1 4-chloro-3-fluoro-2-formylpyridine 
• 152126-31-3 3-fluoro(pyridin-2-yl)carboxylic acid 

Relevant articles and documents

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The invention relates to a novel heterocyclic compound inhibiting a cyclin-dependent kinase (CDK) and a pharmaceutical composition comprising the same as an effective ingredient. The heterocyclic compound according to the present invention or pharmaceutically acceptable salt thereof can be effectively used in treating or preventing cancers, degenerative brain diseases, etc.

PROCESS FOR THE PREPARATION OF N-AMINO SUBSTITUTED HETEROCYCLIC COMPOUNDS

An improved process for the preparation of N-amino nitrogen heterocyclic compounds is disclosed and claimed. In an ambodiment of this invention, a compound of the formula (VI) is prepared starting from the corresponding indole derivative by way of N-amination and subsequently forming an hydrazone by the reaction with a keto compound in a single step. Further reduction of the hydrazone and subsequent coupling with a pyridine compound affords the compound of formula VI or a suitable salt thereof.