(R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide

Base Information

• Chemical Name: (R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide
• CAS No.: 223799-38-0
• Molecular Formula: C₁₇H₁₈ClNO₂
• Molecular Weight: 303.788
• Mol file: 223799-38-0.mol

Synonyms:(R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide

Chemical Property of (R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide

There total 2 articles about (R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-(3-chlorophenoxy)propionic acid (101-10-0) + (S)-1-phenyl-ethylamine (2627-86-3) → (R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide (223799-38-0) + (S)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(99)00169-0

Reference yield:

2-(3-chlorophenoxy)propionic acid (101-10-0) + (-)-α-methylbenzylamine (2627-86-3) → (R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide (223799-38-0) + (S)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide

Guidance literature:

With chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 3h; Yield given; Yields of byproduct given;

DOI:10.1016/S0040-4039(99)00258-0

Reference yield: 33.0%

(R)-2-(3-Chloro-phenoxy)-N-((S)-1-phenyl-ethyl)-propionamide (223799-38-0) → (+)-2-(3-chlorophenoxy)propionic acid

Guidance literature:

With hydrogenchloride; In water; for 17h;

DOI:10.1016/S0040-4039(99)00258-0

upstream raw materials:

2-(3-chlorophenoxy)propionic acid

(S)-1-phenyl-ethylamine

(-)-α-methylbenzylamine

Downstream raw materials:

(R)-(+)-2-(3-chlorophenoxy)propionic acid