(E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

Base Information

Chemical Name:(E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one
CAS No.:1439599-52-6
Molecular Formula:C₂₇H₂₉NO₂Si
Molecular Weight:427.618
Hs Code.:

Synonyms:(E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

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Chemical Property of (E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

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Technology Process of (E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

There total 3 articles about (E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 92552-73-3
1-benzyl-3-hydroxyindolin-2-one

: 103223-44-5
(buta-1,3-dien-2-yl)dimethyl(phenyl)silane

: 1439599-52-6
(E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

Guidance literature:: With dodecacarbonyl-triangulo-triruthenium; tricyclohexylphosphine; In toluene; at 120 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/ol401184k

Reference yield: 67.0%

: 1217-89-6
1-benzylisatin

: 1187817-03-3
(E)-dimethyl(phenyl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-2-ene-2-yl)silane

: 1439599-52-6
(E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

Guidance literature:: With 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; sodium methylate; copper(l) chloride; In 1,4-dioxane; toluene; at -10 - 60 ℃; stereoselective reaction;
DOI:10.1021/acscatal.9b05408

Reference yield:

: 1217-89-6
1-benzylisatin

: 1439599-52-6
(E)-1-benzyl-3-(3-(dimethyl(phenyl)silyl)but-2-en-1-yl)-3-hydroxyindolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / dichloromethane; ethanol / -30 °C / Inert atmosphere

2: dodecacarbonyl-triangulo-triruthenium; tricyclohexylphosphine / toluene / 24 h / 120 °C / Inert atmosphere; Sealed tube

With sodium tetrahydroborate; dodecacarbonyl-triangulo-triruthenium; tricyclohexylphosphine; In ethanol; dichloromethane; toluene;
DOI:10.1021/ol401184k