6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

Base Information

Chemical Name:6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine
CAS No.:1187822-50-9
Molecular Formula:C₂₇H₃₀F₂N₂OSi
Molecular Weight:464.63
Hs Code.:

Synonyms:6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

Suppliers and Price of 6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

There total 4 articles about 6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187820-79-6
5-[3-(tert-butyldimethylsilanyloxymethyl)phenyl]pyridin-2-ylamine

: 135206-83-6
2-bromo-1-(2,4-difluorophenyl)-1-propanone

: 1187822-50-9
6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 80 ℃; for 20h; Screw reactor;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1187822-50-9
6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 16 h / 80 °C / Inert atmosphere

2: 1H-imidazole / tetrahydrofuran / 48 h / 20 °C

3: sodium hydrogencarbonate / ethanol / 20 h / 80 °C / Screw reactor

With 1H-imidazole; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1187822-50-9
6-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 16 h / 80 °C / Inert atmosphere

2: 1H-imidazole / tetrahydrofuran / 48 h / 20 °C

3: sodium hydrogencarbonate / ethanol / 20 h / 80 °C / Screw reactor

With 1H-imidazole; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; toluene;