tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate

Base Information

• Chemical Name: tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate
• CAS No.: 903556-96-7
• Molecular Formula: C₂₃H₂₈N₂O₄
• Molecular Weight: 396.486
• Mol file: 903556-96-7.mol

Synonyms:tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate

Chemical Property of tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate

There total 3 articles about tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

di-tert-butyl dicarbonate (24424-99-5) + benzyl chloroformate (501-53-1,94274-21-2) + 7-cyano-1,2,3,4-tetrahydroisoquinoline (149355-52-2) → tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate (903556-96-7)

Guidance literature:

benzyl chloroformate; 7-cyano-1,2,3,4-tetrahydroisoquinoline; With potassium carbonate; In tetrahydrofuran; water;

di-tert-butyl dicarbonate; With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 - 20 ℃;

Reference yield:

C18H16N2O2 (1030019-28-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate (903556-96-7)

Guidance literature:

C₁₈H₁₆N₂O₂; di-tert-butyl dicarbonate; With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 - 20 ℃;

With 3-azapentane-1,5-diamine; In methanol;

With citric acid; sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

C18H16N2O2 (1030019-28-3) + tert-butyldicarbonate (34619-03-9) → tert-butyl (2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinolin-7-yl)methylcarbamate (903556-96-7)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃;

upstream raw materials:

C₁₈H₁₆N₂O₂

di-tert-butyl dicarbonate

tert-butyldicarbonate

benzyl chloroformate

Refernces

• 1、 -. "HETEROBICYCLIC METALLOPROTEASE INHIBITORS". Page/Page column 179- 180. . Retrieved 2008/12/05.
• 2、 -. "Multicyclic bis-amide MMP inhibitors". Page/Page column 102. . Retrieved 2008/06/13.