Ethyl methyl-p-tolylglycidate

Base Information

• Chemical Name: Ethyl methyl-p-tolylglycidate
• CAS No.: 74367-97-8
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• European Community (EC) Number: 277-844-3
• DSSTox Substance ID: DTXSID00868304
• Nikkaji Number: J318.963E
• Metabolomics Workbench ID: 47786
• Mol file: 74367-97-8.mol

Synonyms:Ethyl methyl-p-tolylglycidate;74367-97-8;ethyl 3-methyl-3-(4-methylphenyl)oxirane-2-carboxylate;Ethyl 2,3-epoxy-3-p-tolylbutyrate;Ethyl methyl-p-methylphenylglycidate;Ethyl 3-methyl-3-(p-tolyl)glycidate;UNII-24HU805Y6Y;FEMA No. 3757;EINECS 277-844-3;Ethyl 3-methyl-3-(4-methylphenyl)oxiranecarboxylate;AI3-07122;24HU805Y6Y;Oxiranecarboxylic acid, 3-methyl-3-(4-methylphenyl)-, ethyl ester;Ethyl methyl-p-tolyl glycidate;SCHEMBL3507914;ethyl methyl-para-tolyl glycidate;FEMA 3757;DTXSID00868304;CHEBI:179456;AKOS015256676;EN300-699099;3-Methyl-3-(4-methylphenyl)oxirane-2-carboxylic acid ethyl ester;Oxiranecarboxylic acid, 3-methyl-3-(4-methylphenyl)-, ethylester

Chemical Property of Ethyl methyl-p-tolylglycidate

Chemical Property:

• Vapor Pressure: 0.00164mmHg at 25°C
• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 119.2°C
• PSA: 38.83000
• Density: 1.116g/cm³
• LogP: 2.17210
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 220.109944368
• Heavy Atom Count: 16
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

ETHYL METHYL PARA-TOLYLGLYCIDATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1C(O1)(C)C2=CC=C(C=C2)C

Technology Process of Ethyl methyl-p-tolylglycidate

There total 4 articles about Ethyl methyl-p-tolylglycidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

chloroacetic acid ethyl ester (105-39-5) + para-methylacetophenone (122-00-9) → ethyl β-methyl-β-(p-methylphenyl)glycidate (36553-42-1,36553-43-2,74367-97-8)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; Ambient temperature;

DOI:10.1016/S0957-4166(00)86007-3

Reference yield: 31.0%

4-methyl-benzaldehyde (104-87-0) + chloroacetic acid ethyl ester (105-39-5) → ethyl β-methyl-β-(p-methylphenyl)glycidate (36553-42-1,36553-43-2,74367-97-8)

Guidance literature:

With ethanol; sodium; In xylene;

Reference yield:

chloroacetic acid ethyl ester (105-39-5) + para-methylacetophenone (122-00-9) → (2RS,3RS)-2,3-epoxy-3-p-tolyl-butyric acid ethyl ester (36553-42-1,36553-43-2,74367-97-8) + (2RS,3SR)-2,3-epoxy-3-p-tolyl-butyric acid ethyl ester (36553-42-1,36553-43-2,74367-97-8)

Guidance literature:

With sodium ethanolate; Petroleum ether;

upstream raw materials:

chloroacetic acid ethyl ester

para-methylacetophenone

4-methyl-benzaldehyde

Downstream raw materials:

C₁₃H₁₆O₃

2-p-tolyl-propionaldehyde-semicarbazone

Trimethyl-((R)-4-methyl-4-p-tolyl-cyclohex-1-enyloxy)-silane

(R)-2-Methyl-5-oxo-2-p-tolyl-cyclopentanecarboxylic acid methyl ester

Refernces

• 1、 Honda, Toshio,Kimura, Nobuaki,Tsubuki, Masayoshi. "Construction of a Chiral Quaternary Carbon Center by Enantioselective Deprotonation: Application to the Formal Synthesis of (+)-α-Cuparenone". . p. 21 - 24. Retrieved 2007/10/02.