trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

Base Information

Chemical Name:trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid
CAS No.:1198101-50-6
Molecular Formula:C₃₁H₂₅F₃N₂O₃
Molecular Weight:530.546
Hs Code.:

Synonyms:trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

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Chemical Property of trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

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Technology Process of trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

There total 6 articles about trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1198101-49-3
trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid methyl ester

: 1198101-50-6
trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

Guidance literature:: trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=< 6;

Reference yield:

: 2062-26-2,87212-84-8,16642-92-5
3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid

: 1198101-50-6
trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

3.2: pH < 6

With thionyl chloride; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; N,N-dimethyl-formamide; In methanol; dichloromethane;

Reference yield:

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 1198101-50-6
trans-(S)-3-phenyl-2-{(4-pyridin-2-yl-benzyl)-[3-(4-trifluoromethyl-phenyl)-acryloyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.2: pH < 6

With water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;