6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

Base Information

• Chemical Name: 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde
• CAS No.: 918643-34-2
• Molecular Formula: C₁₉H₁₀FN₃O₄S
• Molecular Weight: 395.371

Synonyms:6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

Chemical Property of 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

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Technology Process of 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

There total 6 articles about 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine (1123838-08-3) → 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde (918643-34-2)

Guidance literature:

With water; acetic acid; at 90 ℃; for 18h;

Reference yield: 55.0%

6-(7-chlorothieno[3,2-b]pyridin-2-yl)nicotinaldehyde (1123838-30-1) + 2-fluoro-4-nitrophenol (403-19-0) → 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde (918643-34-2)

Guidance literature:

With potassium carbonate; In diphenylether; at 180 ℃; Product distribution / selectivity;

Reference yield: 50.0%

7-(2-fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine (918643-33-1) + 6-bromonicotinaldehyde (149806-06-4) → 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde (918643-34-2)

Guidance literature:

With hexamethyldistannane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 20h;

upstream raw materials:

7-(2-fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine

6-bromonicotinaldehyde

6-(7-chlorothieno[3,2-b]pyridin-2-yl)nicotinaldehyde

2-fluoro-4-nitrophenol

Downstream raw materials:

N-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-methoxyethanamine

2-(5-(diethoxymethyl)pyridin-2-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine

4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

N-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-(2-methoxyethoxy)ethanamine

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