4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

Base Information

Chemical Name:4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine
CAS No.:1187214-12-5
Molecular Formula:C₂₃H₁₉FN₄O₄S
Molecular Weight:466.493
Hs Code.:

Synonyms:4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

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Chemical Property of 4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

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Technology Process of 4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

There total 4 articles about 4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.8%

: 110-91-8,99108-56-2
morpholine

: 918643-34-2
6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

: 1187214-12-5
4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

Guidance literature:: morpholine; 6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1187214-12-5
4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: camphor-10-sulfonic acid / toluene / 0.83 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -10 - -5 °C

2.2: 1.58 h / -10 - 20 °C

2.3: 2 h / Reflux

3.1: sodium carbonate / diphenylether / 2 h / 180 °C

4.1: water; acetic acid / 18 h / 90 °C

5.1: acetic acid / dichloromethane / 1 h / 20 °C

With n-butyllithium; water; sodium carbonate; acetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; diphenylether; dichloromethane; toluene;

Reference yield:

: 334987-30-3
2-bromo-5-(1,3-dioxan-2-yl)pyridine

: 1187214-12-5
4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -10 - -5 °C

1.2: 1.58 h / -10 - 20 °C

1.3: 2 h / Reflux

2.1: sodium carbonate / diphenylether / 2 h / 180 °C

3.1: water; acetic acid / 18 h / 90 °C

4.1: acetic acid / dichloromethane / 1 h / 20 °C

With n-butyllithium; water; sodium carbonate; acetic acid; In tetrahydrofuran; hexanes; diphenylether; dichloromethane;