(6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

Chemical Name:(6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone
CAS No.:1332526-34-7
Molecular Formula:C₂₄H₂₀FNO₆S
Molecular Weight:469.49
Hs Code.:

Synonyms:(6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone

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Technology Process of (6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone

There total 2 articles about (6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.7%

: 840474-96-6
6-fluoro-1-(phenylsulfonyl)-1H-indole

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1332526-34-7
(6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: 6-fluoro-1-(phenylsulfonyl)-1H-indole; With tert.-butyl lithium; In tetrahydrofuran; pentane; for 0.166667h; Inert atmosphere;

3,4,5-Trimethoxybenzoyl chloride; In tetrahydrofuran; pentane; at -78 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.084

Reference yield:

: 399-51-9
6-fluoro-1H-indole

: 98-09-9
benzenesulfonyl chloride

: 1332526-34-7
(6-fluoro-1-(phenylsulfonyl)-1H-indol-2-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran; mineral oil; pentane;
DOI:10.1016/j.bmc.2011.06.084