4-Chlorobenzohydrazide

Base Information

• Chemical Name: 4-Chlorobenzohydrazide
• CAS No.: 536-40-3
• Molecular Formula: C7H7ClN2O
• Molecular Weight: 170.598
• Hs Code.: 29280000
• European Community (EC) Number: 208-632-0
• NSC Number: 54990
• DSSTox Substance ID: DTXSID40201817
• Nikkaji Number: J6.352E
• Wikidata: Q72517162
• ChEMBL ID: CHEMBL125812
• Mol file: 536-40-3.mol

Synonyms:4-Chlorobenzohydrazide;4-Chlorobenzhydrazide;536-40-3;4-Chlorobenzoic Hydrazide;4-Chlorobenzoylhydrazine;p-Chlorobenzohydrazide;4-Chlorobenzoic acid hydrazide;Benzoic acid, 4-chloro-, hydrazide;p-Chlorobenzoylhydrazine;p-Chlorobenzoic hydrazide;p-Chlorobenzoyl hydrazide;4-Chlorobenzoyl hydrazide;p-Chlorobenzoic acid, hydrazide;4-Chlorobenzoic acid, hydrazide;P-CHLOROBENZHYDRAZIDE;MFCD00007603;NSC 54990;MLS000402191;4-Chloro-benzoic acid hydrazide;Benzoic acid, p-chloro-, hydrazide;EINECS 208-632-0;SMR000263809;4-chlorobenzene-1-carbohydrazide;4-chlorobenzenecarbohydrazide;4ClPhCON2;4-chloro-benzhydrazide;4-chloranylbenzohydrazide;4-chlorobenzoyl hydrazine;Opera_ID_1071;(p-chlorobenzoyl)hydrazine;(4-Chlorobenzoyl)hydrazine;4-Chlorobenzhydrazide, 98%;SCHEMBL165164;CHEMBL125812;DTXSID40201817;HMS2529I20;NSC54990;STR01242;AM9913;BBL003589;NSC-54990;STK039718;AKOS000194880;SB85905;NCGC00246092-01;SY035573;Boc-o-Benzyl-L-threoninep-nitrophenylester;C2060;CS-0142936;FT-0618179;EN300-17501;A829699;Z56945552;F1171-0133

Chemical Property of 4-Chlorobenzohydrazide

Chemical Property:

• Appearance/Colour: white to light beige crystals
• Vapor Pressure: 4.99E-05mmHg at 25°C
• Melting Point: 162-165 °C(lit.)
• Refractive Index: 1.592
• Boiling Point: 334.6 °C at 760 mmHg
• PKA: 12.09±0.10(Predicted)
• Flash Point: 156.2 °C
• Density: 1.323 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 143

Purity/Quality:

99% ^*data from raw suppliers

4-Chlorobenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)NN)Cl
• Uses: 4-Chlorobenzhydrazide has been used in preparation of:rod-shaped mesogenic hydrazide derivatives via Schotten-Baumann reaction with 4-n-alkoxybenzoyl chloride4-methoxybenzaldehyde-4-chlorophenyl-1-carbonyl hydrazone4-hydroxybenzaldehyde-4-chlorophenyl-1-carbonylhydrazone2-nitrobenzaldehyde-4-chlorophenyl-1-carbonylhydrazonebenzaldehyde-4-chlorophenyl-1-carbonylhydrazone

Technology Process of 4-Chlorobenzohydrazide

There total 20 articles about 4-Chlorobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl 4-chlorobenzoate (1126-46-1) → 4-chlorobenzoic acid hydrazide (536-40-3)

Guidance literature:

With hydrazine;

Reference yield: 93.2%

ethyl 4-chlorobenzoate (7335-27-5) → 4-chlorobenzoic acid hydrazide (536-40-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 4h; Reflux;

DOI:10.1007/s00044-012-0270-0

Reference yield: 91.0%

para-chlorobenzoic acid (74-11-3) → 4-chlorobenzoic acid hydrazide (536-40-3)

Guidance literature:

para-chlorobenzoic acid; With sulfuric acid; In ethanol; for 6h; Reflux;

With hydrazine hydrate; sodium hydrogencarbonate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2017.06.036

upstream raw materials:

ethyl 4-chlorobenzoate

Methyl 4-chlorobenzoate

4-nitrophenyl 4-chlorobenzoate

p-chlorobenzoyl isothiocyanate

Downstream raw materials:

4-chloro-thiobenzoic acid-([2]quinolylmethylene-hydrazide)

N’-acetyl-4-chlorobenzohydrazide

3-(4-chloro-benzoylhydrazono)-butyric acid ethyl ester

4-chloro-N'-[(1E)-4-nitrophenylmethylidene]benzohydrazide