(Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

Base Information

Chemical Name:(Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide
CAS No.:1268630-74-5
Molecular Formula:C₁₃H₁₉NO₄S
Molecular Weight:285.364
Hs Code.:

Synonyms:(Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

Chemical Property:

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Technology Process of (Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

There total 5 articles about (Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1268631-08-8
C₂₃H₃₅NO₆S

: 1268630-74-5
(Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 80 ℃; for 24h;
DOI:10.1002/chem.201002606

Reference yield: 60.0%

: 14316-14-4
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

: cis-1-bromo-but-2-en-4-ol

: 1268630-74-5
(Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

Guidance literature:: N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

cis-1-bromo-but-2-en-4-ol; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.joc.6b02260

Reference yield:

: C₁₄H₂₁NO₄S

: 1268630-74-5
(Z)-N-(4-hydroxybut-2-en-1-yl)-N-(2-hydroxyethyl)-4-methylbenzene-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / tetrahydrofuran; water / 24 h / 80 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; water; mineral oil;
DOI:10.1002/chem.201002606