(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

Base Information

Chemical Name:(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione
CAS No.:127042-96-0
Molecular Formula:C₃₆H₄₅N₃S
Molecular Weight:551.839
Hs Code.:

Synonyms:(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

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Chemical Property of (R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

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Technology Process of (R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

There total 10 articles about (R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 463-71-8
thiophosgene

: 127042-95-9
(R)-N²-((R)-2-Amino-2-cyclohexyl-ethyl)-1-cyclohexyl-N¹-trityl-ethane-1,2-diamine

: 127042-96-0
(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

Guidance literature:: With triethylamine; 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h;
DOI:10.1016/S0040-4039(01)93748-7

Reference yield:

: 700-63-0,6485-52-5,6485-67-2,58429-87-1
(R)-phenylglycine amide

: 127042-96-0
(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / H₂ / Admams' Pt / acetic acid / 40 h / 23 °C / 760 Torr

2: 94 percent / triethylamine / CH₂Cl₂ / 2.5 h / 23 °C

3: 97 percent / lithium aluminium hydride / diethyl ether / 40 h / Heating

4: 85 percent / tetrahydrofuran

5: 100 percent / H₂ / Pd-C / methanol / 23 °C / 760 Torr

6: 100 percent / bis(2-methoxyethoxy)aluminium dihydride / benzene / 0.67 h / Heating

7: 69 percent / triethylamine / 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h

With lithium aluminium tetrahydride; bis(2-methoxyethoxy)aluminium dihydride; hydrogen; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid; benzene;
DOI:10.1016/S0040-4039(01)93748-7

Reference yield:

: 127042-98-2
D-(-)-cyclohexylglycine amide

: 127042-96-0
(R)-4-Cyclohexyl-1-[(R)-2-cyclohexyl-2-(trityl-amino)-ethyl]-imidazolidine-2-thione

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / triethylamine / CH₂Cl₂ / 2.5 h / 23 °C

2: 97 percent / lithium aluminium hydride / diethyl ether / 40 h / Heating

3: 85 percent / tetrahydrofuran

4: 100 percent / H₂ / Pd-C / methanol / 23 °C / 760 Torr

5: 100 percent / bis(2-methoxyethoxy)aluminium dihydride / benzene / 0.67 h / Heating

6: 69 percent / triethylamine / 1.)-50 deg C to -30 deg C for 2 h, 2.)23 deg C 1 h

With lithium aluminium tetrahydride; bis(2-methoxyethoxy)aluminium dihydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)93748-7