Des-N,N-diethylethanaMine 4-HydroxycloMiphene

Base Information

Chemical Name:Des-N,N-diethylethanaMine 4-HydroxycloMiphene
CAS No.:53775-07-8
Molecular Formula:C₂₀H₁₅ClO
Molecular Weight:306.791
Hs Code.:
Mol file:53775-07-8.mol

Synonyms:(cis/trans)-1-chloro-2-(4-hydroxyphenyl)-1,2-diphenyl-ethene

Suppliers and Price of Des-N,N-diethylethanaMine 4-HydroxycloMiphene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Des-N,N-diethylethanamine4-Hydroxyclomiphene
100mg
$ 1540.00

Total 3 raw suppliers

Chemical Property of Des-N,N-diethylethanaMine 4-HydroxycloMiphene

Chemical Property:

Melting Point:101-103 °C
Boiling Point:425.7±40.0 °C(Predicted)
PKA:8.37±0.15(Predicted)
Density:1.216±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Des-N,N-diethylethanamine4-Hydroxyclomiphene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Des-N,N-diethylethanaMine 4-Hydroxyclomiphene is a derivative of Clomiphene (C587025), a synthetic estrogen agonist-antagonist. Des-N,N-diethylethanamine Hydroxyclomiphene is a derivative of Clomiphene (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility. Used in the synthesis of gonadotropin inhibitor

Technology Process of Des-N,N-diethylethanaMine 4-HydroxycloMiphene

There total 9 articles about Des-N,N-diethylethanaMine 4-HydroxycloMiphene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 53775-08-9
4-(2-chloro-1,2-diphenylvinyl)anisole

: 53775-07-8
(cis/trans)-1-chloro-2-(4-hydroxyphenyl)-1,2-diphenyl-ethene

Guidance literature:: With boron tribromide; In dichloromethane; at -60 - 0 ℃;
DOI:10.1021/acs.oprd.1c00366

Reference yield: 86.0%

: (cis/trans)-2-(4-benzyloxyphenyl)-1-chloro-1,2-diphenyl-ethene

: 53775-07-8
(cis/trans)-1-chloro-2-(4-hydroxyphenyl)-1,2-diphenyl-ethene

Guidance literature:: With hydrogenchloride; In acetic acid; for 6h; Heating;
DOI:10.1002/jps.2600820911

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 53775-07-8
(cis/trans)-1-chloro-2-(4-hydroxyphenyl)-1,2-diphenyl-ethene

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 1.5 h / 20 - 46 °C

1.2: 60 °C / Sealed tube; Inert atmosphere

1.3: 1 h / 20 - 25 °C

2.1: boron tribromide / dichloromethane / -60 - 0 °C

With boron tribromide; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.oprd.1c00366