9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Base Information

Chemical Name:9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine
CAS No.:1301628-61-4
Molecular Formula:C₄₂H₄₀N₆O₇
Molecular Weight:740.816
Hs Code.:

Synonyms:9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

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Chemical Property of 9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

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Technology Process of 9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

There total 3 articles about 9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1301628-60-3
9-[4-C-allyl-3,5-di-O-benzyl-2-O-acetyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

: 1301628-61-4
9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/jo200073q

Reference yield:

: 945382-94-5
C₂₆H₃₀O₇

: 1301628-61-4
9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / 1,2-dichloro-ethane / 0.5 h / 80 °C / Inert atmosphere

1.2: 1 h / 80 °C / Inert atmosphere

2.1: water; sodium hydroxide / tetrahydrofuran / 0 °C

With N,O-bis-(trimethylsilyl)-acetamide; water; sodium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/jo200073q

Reference yield:

: 945382-92-3
4-C-allyl-3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranose

: 1301628-61-4
9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid; acetic acid / dichloromethane / 0.5 h / 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / 1,2-dichloro-ethane / 0.5 h / 80 °C / Inert atmosphere

2.2: 1 h / 80 °C / Inert atmosphere

3.1: water; sodium hydroxide / tetrahydrofuran / 0 °C

With N,O-bis-(trimethylsilyl)-acetamide; trifluorormethanesulfonic acid; water; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo200073q