9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Base Information

Chemical Name:9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine
CAS No.:1301628-62-5
Molecular Formula:C₄₉H₄₄N₆O₈S
Molecular Weight:876.99
Hs Code.:

Synonyms:9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Suppliers and Price of 9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

There total 4 articles about 9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1301628-61-4
9-[4-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

: 1005-56-7
phenylcarbonochloridothioate

: 1301628-62-5
9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Guidance literature:: With 1-methyl-1H-imidazole; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo200073q

Reference yield:

: 945382-94-5
C₂₆H₃₀O₇

: 1301628-62-5
9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / 1,2-dichloro-ethane / 0.5 h / 80 °C / Inert atmosphere

1.2: 1 h / 80 °C / Inert atmosphere

2.1: water; sodium hydroxide / tetrahydrofuran / 0 °C

3.1: 1-methyl-1H-imidazole / dichloromethane / 0 - 20 °C

With 1-methyl-1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; water; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo200073q

Reference yield:

: 945382-92-3
4-C-allyl-3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranose

: 1301628-62-5
9-[4-C-allyl-3,5-di-O-benzyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl]-N2-acetyl-O6-diphenylcarbamoylguanine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid; acetic acid / dichloromethane / 0.5 h / 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / 1,2-dichloro-ethane / 0.5 h / 80 °C / Inert atmosphere

2.2: 1 h / 80 °C / Inert atmosphere

3.1: water; sodium hydroxide / tetrahydrofuran / 0 °C

4.1: 1-methyl-1H-imidazole / dichloromethane / 0 - 20 °C

With 1-methyl-1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; trifluorormethanesulfonic acid; water; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo200073q