(2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

Base Information

Chemical Name:(2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone
CAS No.:1215119-74-6
Molecular Formula:C₂₀H₂₀F₃NO
Molecular Weight:347.38
Hs Code.:

Synonyms:(2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

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Technology Process of (2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

There total 3 articles about (2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 22780-11-6
1-(2,2,2-trichloroacetoxy)cyclohexene

: 79128-83-9
N-(4-(trifluoromethyl)benzylidene)aniline

: 1215119-74-6
(2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

Guidance literature:: With 2,2,2-trifluoroethanol; silver trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; (R)-segphos; In tetrahydrofuran; at -30 ℃; for 9h; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ol403075u

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 62-53-3
aniline

: 1215119-74-6
(2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

: 1393116-45-4
(R)-2-((R)-(phenylamino)(4-(trifluoromethyl)phenyl)methyl)cyclohexanone

: 2-((phenylamino)(4-(trifluoromethyl)phenyl)methyl)cyclohexanone

Guidance literature:: With acylase I from Aspergillus melleus; In aq. phosphate buffer; acetonitrile; at 30 ℃; for 119h; pH=8.1; Overall yield = 78 %; stereoselective reaction; Green chemistry; Enzymatic reaction;
DOI:10.1016/j.molcatb.2014.11.007

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 62-53-3
aniline

: 1215119-74-6
(2S,1’S)-2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

: 2-[(phenylamino)(4-(trifluoromethyl)phenyl)methyl]cyclohexanone

Guidance literature:: With methyl 2-amino-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside; benzoic acid; In dichloromethane; at 20 ℃; for 48h; Overall yield = 76 %; Overall yield = 53 mg; stereoselective reaction;
DOI:10.1055/s-0036-1591740