ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate

Base Information

• Chemical Name: ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate
• CAS No.: 76367-45-8
• Molecular Formula: C₃₅H₄₀N₂O₆
• Molecular Weight: 584.712
• Mol file: 76367-45-8.mol

Synonyms:ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate

Chemical Property of ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate

There total 5 articles about ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 3,3-diethoxypropanoate (10601-80-6) + 2-benzyloxycarbonyl-3-ethyl-4-methylpyrrole (5866-56-8) → ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate (76367-45-8)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 24h; Heating;

DOI:10.1021/ja00393a007

Reference yield:

2-(ethyloxycarbonyl)-3-ethyl-4-methylpyrrole (4949-58-0) → ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate (76367-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / base-catalyzed transesterification

2: 72 percent / p-toluenesulphonic acid / benzene / 24 h / Heating

With toluene-4-sulfonic acid; In benzene;

DOI:10.1021/ja00393a007

Reference yield:

5-Ethoxycarbonyl-4-ethyl-3-methylpyrrole-2-carboxylic acid (5012-24-8) → ethyl 3,3-bis(5-((benzyloxy)carbonyl)-4-ethyl-3-methylpyrrol-2-yl)-propionate (76367-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / I₂, NaI, NaHCO₃ / H₂O; 1,2-dichloro-ethane / 1 h / Heating

2: 80 percent / NaI, HCl / ethanol; H₂O / 0.25 h / Heating

3: 95 percent / base-catalyzed transesterification

4: 72 percent / p-toluenesulphonic acid / benzene / 24 h / Heating

With hydrogenchloride; iodine; sodium hydrogencarbonate; toluene-4-sulfonic acid; sodium iodide; In ethanol; water; 1,2-dichloro-ethane; benzene;

DOI:10.1021/ja00393a007

upstream raw materials:

ethyl 3,3-diethoxypropanoate

2-benzyloxycarbonyl-3-ethyl-4-methylpyrrole

2-(ethyloxycarbonyl)-3-ethyl-4-methylpyrrole

5-Ethoxycarbonyl-4-ethyl-3-methylpyrrole-2-carboxylic acid