4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

Base Information

Chemical Name:4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one
CAS No.:124021-56-3
Molecular Formula:C₂₅H₃₁NO₄
Molecular Weight:409.525
Hs Code.:

Synonyms:4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

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Chemical Property of 4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

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Technology Process of 4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

There total 6 articles about 4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 124021-62-1
(E)-4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-but-3-en-2-one

: 124021-56-3
4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetone; for 4h; under 2844.3 Torr;
DOI:10.1021/jo00286a007

Reference yield:

: 100-39-0
benzyl bromide

: 124021-56-3
4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 3 h

2: 89 percent / lithium aluminum hydride / diethyl ether / 0.75 h / 0 °C

3: 73 percent / NaH / toluene / 36 h / Heating

4: 96 percent / H₂ / 5percent Pd/C / acetone / 4 h / 2844.3 Torr

With lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetone; toluene;
DOI:10.1021/jo00286a007

Reference yield:

: 117917-45-0
8,9-Dimethoxy-1-oxo-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline-10b-carboxylic acid tert-butyl ester

: 124021-56-3
4-(1-Benzyloxy-8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolin-10b-yl)-butan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / sodium cyanoborohydride / acetic acid / 1.5 h / 0 - 20 °C

2: NaH / tetrahydrofuran / 3 h

3: 89 percent / lithium aluminum hydride / diethyl ether / 0.75 h / 0 °C

4: 73 percent / NaH / toluene / 36 h / Heating

5: 96 percent / H₂ / 5percent Pd/C / acetone / 4 h / 2844.3 Torr

With lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; acetone; toluene;
DOI:10.1021/jo00286a007